Behind the headlines - Winter 2023

8 February 2023
Winter 2023

Eye health issues that are making the news - Winter 2023.

RPE65 drives visual cycle

Researchers have identified new details about the role of vitamin A in enabling the eye to sense light. The discovery could inform the hunt for new therapies for a number of visual impairments.

When light hits photosensitive pigments called opsins in the retina, a chemical called 11-cis retinal, derived from vitamin A, is converted into the molecule all-trans retinol. This triggers chemical reactions that generate the electrical signals that form the basis of vision in the brain.

The retinal pigment epithelium (RPE) drives the reversal of this process to restore the sensitivity of opsins to light, enabling the visual cycle to begin again. A protein called RPE65 plays a key role by binding to RPE cells.

Sign in to continue

Forgotten password?
Register

Not already a member of the College?

Start enjoying the benefits of College membership today. Take a look at what the College can offer you and view our membership categories and rates.

Related further reading

The celebrations are a chance to pay tribute to NHS staff.

The College issues eye health advice as more families consider hosting their own fireworks display.

We believe that vaccine uptake will be maximised when staff are supported to make their own decisions, having been provided with clear, evidence-based information on the benefit and value of vaccinations.