The CMGs offer information on the diagnosis and management of a range of conditions that present with varying frequency in primary and first contact care.
The CMGs offer information on the diagnosis and management of a range of conditions that present with varying frequency in primary and first contact care.
Contact lens-associated papillary conjunctivitis (CLAPC) is an inflammatory condition which causes characteristic redness and roughness of the upper tarsal conjunctiva (giant papillary conjunctivitis, GPC). Similar symptoms can be seen in response to ocular prosthetics and exposed sutures. This Clinical Management Guideline outlines the aetiology, signs, symptoms and evidence-based recommendations for diagnosing and treating CLAPC. It provides a summary of non-pharmacological management approaches and pharmacological treatment options to manage this condition.
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What is contact lens-associated papillary conjunctivitis?
Contact lens-associated papillary conjunctivitis (CLAPC) is an inflammatory condition affecting the transparent membrane which lines the back of the upper eyelid (tarsal conjunctiva). It can occur in people wearing soft or rigid contact lenses or an ocular prosthesis (artificial eye). People suffering from this condition experience eye irritation, which may lead them to abandon contact lens wear. The eyes are often red and the underside of the upper lid shows minute cobblestone-like swellings called papillae.
How is contact lens-associated papillary conjunctivitis managed?
Treatment for CLAPC initially consists of improving contact lens hygiene, optimising lens fit and replacing lenses more frequently. Eye drops such as anti-histamines or mast cell stabilisers are often required to relieve symptoms and improve clinical signs. In more severe cases it may be necessary to use steroid eye drops for short periods.
CL-associated Papillary Conjunctivitis (CLAPC) Giant Papillary Conjunctivitis (GPC) - 14 October 2025 The predisposing factors section has been amended to include additional patient features which increase the risk of developing GPC. The signs section has been revised to set out the typical presentation of CLAPC. The non-pharmacological section has been amended to stress the importance of addressing contact lens wear compliance, hygiene and fitting as the initial management in CLAPC. The management category has been revised to consider referral for GPC caused by exposed sutures or an extruded scleral buckle.
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